| 存储条件 |
|---|
| Product Name | Axin2 [JM11-30] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Axil antibody Axin like protein antibody Axin-2 antibody Axin-like protein antibody Axin2 antibody AXIN2_HUMAN antibody Axis inhibition protein 2 antibody Conductin antibody DKFZp781B0869 antibody MGC10366 antibody MGC126582 antibody |
| Product description | b-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of b-catenin, by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor-T cell factor family and modulation of gene expression. Axin is involved in the degradation of b-catenin by acting as a scaffold to form a complex between b-catenin, adenomatous polyposis coli (APC) and GSK-3b. APC, which is phosphorylated by GSK-3b, induces degradation of b-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to axin and appears to play a similar role to axin in the Wnt signaling pathway. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IFIHC |
| WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:10-1:50 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | Axil antibody Axin like protein antibody Axin-2 antibody Axin-like protein antibody Axin2 antibody AXIN2_HUMAN antibody Axis inhibition protein 2 antibody Conductin antibody DKFZp781B0869 antibody MGC10366 antibody MGC126582 antibody |
|---|---|
| Molecular Weight(MW) | 94 kDa |
| Cellular Localization | Cytoplasm. |
Application
Fig1: Western blot analysis of Axin2 on SW480 cells lysates using anti-Axin2 antibody at 1/500 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Axin2 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Axin2 antibody. Counter stained with hematoxylin.| Positive Control | SW480, mouse colon tissue, mouse brain tissue. |
|---|---|
| Application Notes | WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:10-1:50 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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