Cell adhesion molecules are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to play an important role in embryogenesis and development. Neuronal cell adhesion molecule (NCAM) expression is observed in a variety of human tumors, including neuroblastomas, rhabdomyosarcomas, Wilm's tumors, Ewing's sarcomas and some primitive myeloid malignancies. The NCAM-L1 adhesion molecule (CD171) plays an important role in axon guidance and cell migration in the nervous system. The presence of NCAM-L1 might contribute to tumor progression by promoting cell adhesion and migration and is known to be expressed by neurons, neuroblastomas and other malignant tumors.
Fig1: Western blot analysis of L1CAM on different cells lysates using anti-L1CAM antibody at 1/500 dilution. Positive control： Line 1: Hela Line 2: human brain
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-L1CAM antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human thyroid tissue using anti-L1CAM antibody. Counter stained with hematoxylin.
Positive Control
Hela, human brain, human kidney tissue, human thyroid tissue.
Application Notes
WB:1:1,000-1:5,000 IHC:1:50-1:200
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
