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| Product Name | CD26 [JM11-42] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CD26 antigen antibody ADA-binding protein antibody ADABP antibody ADCP 2 antibody ADCP-2 antibody ADCP2 antibody Adenosine deaminase complexing protein 2 antibody CD 26 antibody CD26 antibody CD26 antigen 3 antibody Dipeptidyl peptidase 4 antibody Dipeptidyl peptidase 4 soluble form antibody Dipeptidyl peptidase IV antibody Dipeptidyl peptidase IV membrane form antibody Dipeptidyl peptidase IV soluble form antibody Dipeptidyl peptidase, intestinal antibody Dipeptidylpeptidase 4 antibody Dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) antibody Dipeptidylpeptidase IV antibody DPP 4 antibody DPP IV antibody DPP IV estoenzyme antibody DPP4 antibody DPP4_HUMAN antibody DPPIV antibody Intestinal dipeptidyl peptidase antibody T cell activation antigen CD26 antibody T-cell activation antigen CD26 antibody TP 103 antibody TP103 antibody |
| Product description | CD26 (dipeptidylpeptidase 4, adenosine deaminase complexing protein 2, ADABP, ADCP2, DPPIV, TP103) is a membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. CD26 has an essential role in immune regulation as a T cell activation molecule and a regulator of chemokine function. CD26 associates with CXCR4 and gp120 and may influence the pathophysiology of HIV infection. Adenosine deaminase (ADA) colocalizing with adenosine receptors on dendritic cells are able to interact with CD26 expressed on lymphocytes. This costimulatory signal in the immunological synapse leads to an increase in the production of the T helper 1 and proinflammatory cytokines IFN-gamma, TNF-alpha, and IL-6. CD26 plays a role in the pathogenesis and behavior of human cancers, including solid tumors and hematological malignancies. CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IFIHCFC |
| WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:100 FC:1:50-1:100 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | CD26 antigen antibody ADA-binding protein antibody ADABP antibody ADCP 2 antibody ADCP-2 antibody ADCP2 antibody Adenosine deaminase complexing protein 2 antibody CD 26 antibody CD26 antibody CD26 antigen 3 antibody Dipeptidyl peptidase 4 antibody Dipeptidyl peptidase 4 soluble form antibody Dipeptidyl peptidase IV antibody Dipeptidyl peptidase IV membrane form antibody Dipeptidyl peptidase IV soluble form antibody Dipeptidyl peptidase intestinal antibody Dipeptidylpeptidase 4 antibody Dipeptidylpeptidase IV (CD26 adenosine deaminase complexing protein 2) antibody Dipeptidylpeptidase IV antibody DPP 4 antibody DPP IV antibody DPP IV estoenzyme antibody DPP4 antibody DPP4_HUMAN antibody DPPIV antibody Intestinal dipeptidyl peptidase antibody T cell activation antigen CD26 antibody T-cell activation antigen CD26 antibody TP 103 antibody TP103 antibody |
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| Molecular Weight(MW) | 110 kDa |
| Cellular Localization | Cell membrane. |
Application
Fig1: Western blot analysis of CD26 on mouse heart cells lysates using anti-CD26 antibody at 1/500 dilution.
Application
Fig2: ICC staining CD26 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining CD26 in PC-12 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-CD26 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded rat epididymis tissue using anti-CD26 antibody. Counter stained with hematoxylin.
Application
Fig6: Flow cytometric analysis of Hela cells with CD26 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.| Positive Control | Mouse heart cells lysates, PC-12, Hela, human liver tissue, rat epididymis tissue. |
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| Application Notes | WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:100 FC:1:50-1:100 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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