| 存储条件 |
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| Product Name | ERp57 [JM11-44] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 58 kDa glucose regulated protein antibody 58 kDa glucose-regulated protein antibody 58 kDa microsomal protein antibody Disulfide isomerase ER 60 antibody Disulfide isomerase ER-60 antibody Endoplasmic reticulum resident protein 57 antibody Endoplasmic reticulum resident protein 60 antibody ER p57 antibody ER protein 57 antibody ER protein 60 antibody ERp 57 antibody ERp57 antibody ERp60 antibody ERp61 antibody Glucose Regulated Protein 58 Kd antibody GRP 57 antibody GRP 58 antibody GRP57 antibody HsT17083 antibody p58 antibody PDIA 3 antibody PDIA3 antibody PDIA3_HUMAN antibody Phospholipase C alpha antibody PI PLC antibody Protein disulfide isomerase A3 antibody Protein disulfide isomerase family A member 3 antibody Protein disulfide-isomerase A3 antibody |
| Product description | Mammals defend themselves against intracellular pathogens through presentation of cytoplasmically-derived short pathogenic peptides to the cell surface of cytotoxic T lymphocytes, which subsequently leads to cytotoxic events with respect to the affected cell. Antigen presentation is mediated by major histocompatibility complex (MHC) class I molecules, which bind and coordinate short pathogenic peptides. MHC class I molecules assemble in the endoplasmic reticulum with chaperones before binding to the transporter associated with antigen processing (TAP). ERp57, also designated GRP57, GRP58, ERp60 and ERp61, is a component of the MHC class I pathway that appears to interact with MHC class I molecules before they associate with TAP. The human ERp57 gene maps to chromosome 15q15 and encodes a 505 amino acid protein. ERp57 has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved among the mammals. ERp57 may act as a protease, a protein disulfide isomerase, a phospholipase or a combination of these. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIPIHC |
| WB:1:500-1:1,000 IHC:1:50-1:200 IP:1:10-1:50 | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | 58 kDa glucose regulated protein antibody 58 kDa glucose-regulated protein antibody 58 kDa microsomal protein antibody Disulfide isomerase ER 60 antibody Disulfide isomerase ER-60 antibody Endoplasmic reticulum resident protein 57 antibody Endoplasmic reticulum resident protein 60 antibody ER p57 antibody ER protein 57 antibody ER protein 60 antibody ERp 57 antibody ERp57 antibody ERp60 antibody ERp61 antibody Glucose Regulated Protein 58 Kd antibody GRP 57 antibody GRP 58 antibody GRP57 antibody HsT17083 antibody p58 antibody PDIA 3 antibody PDIA3 antibody PDIA3_HUMAN antibody Phospholipase C alpha antibody PI PLC antibody Protein disulfide isomerase A3 antibody Protein disulfide isomerase family A member 3 antibody Protein disulfide-isomerase A3 antibody |
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| Molecular Weight(MW) | 55 kDa |
| Cellular Localization | Endoplasmic reticulum lumen. Melanosome. |
| SwissProt ID | P30101 |
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Application
Fig1: Western blot analysis of ERp57 on different cells lysates using anti-ERp57 antibody at 1/500 dilution. Positive control： Line 1: Hela Line 2: HepG2 Line 3:293T
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ERp57 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-ERp57 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-ERp57 antibody. Counter stained with hematoxylin.| Positive Control | HepG2, 293T, Hela, human pancreas tissue, human kidney tissue, human uterus tissue. |
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| Application Notes | WB:1:500-1:1,000 IHC:1:50-1:200 IP:1:10-1:50 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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