| 存储条件 |
|---|
| Product Name | Integrin beta 4 [JM11-06] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Integrin β4 (ITGB4), also known as CD104, is a 1,822 amino acid single-pass type I membrane protein belonging to the Integrin β chain family. Known to associate with Integrin α6, Integrin β4 functions as a receptor for Laminin and is predominantly expressed by epithelia. Integrin β4 exists as five alternatively spliced isoforms that are encoded by a gene located on human chromosome 17q25.1. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WB,IHC |
| WB:1:1,000-1:2,000 IHC:1:50-1:200 | |
| Species Reactivity | Human,Mouse |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | CD 104 antibody CD104 antibody CD104 antigen antibody gp150 antibody Integrin beta 4 subunit antibody Integrin beta-4 antibody ITB4_HUMAN antibody ITG B4 antibody ITGB 4 antibody Itgb4 antibody |
|---|---|
| Molecular Weight(MW) | 210 kDa |
| Cellular Localization | Membrane. |
Application
using anti-Integrin beta 4 antibody at 1/500 dilution. Positive control： Line 1: A431 Line 2: A549
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-Integrin beta 4 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Integrin beta 4 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Integrin beta 4 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Integrin beta 4 antibody. Counter stained with hematoxylin.| Positive Control | A431, A549, human breast cancer tissue, human tonsil tissue, human pancreas tissue, mouse colon tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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