| 存储条件 |
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| Product Name | PRDX6 [JM11-13] |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | 1 Cys antibody 1 Cys peroxiredoxin antibody 1 Cys PRX antibody 1 cysPrx antibody 1-Cys peroxiredoxin antibody 1-Cys PRX antibody 24 kDa protein antibody 9430088D19Rik antibody AA690119 antibody Acidic calcium independent phospholipase A2 antibody Acidic calcium-independent phospholipase A2 antibody aiPLA2 antibody Antioxidant protein 2 antibody AOP2 antibody Aop2 rs3 antibody Brp 12 antibody Ciliary body glutathione peroxidase antibody CP 3 antibody EC 1.11.1.15 antibody EC 1.11.1.7 antibody EC 3.1.1. antibody Epididymis secretory sperm binding protein Li 128m antibody GPx antibody HEL S 128m antibody KIAA0106 antibody Liver 2D page spot 40 antibody Ltw4 antibody Lvtw 4 antibody MGC46173 antibody mKIAA0106 antibody Non selenium glutathione peroxidase antibody Non-selenium glutathione peroxidase antibody NSGPx antibody ORF06 antibody OTTHUMP00000032693 antibody p29 antibody Peroxiredoxin-6 antibody Peroxiredoxin6 antibody PHGPx antibody Phospholipase A2 lysosomal antibody PLA2 antibody PRDX 6 antibody Prdx5 antibody PRDX6 antibody Prdx6 rs3 antibody PRDX6_HUMAN antibody PRX antibody Red blood cells page spot 12 antibody Thiol specific antioxidant protein antibody |
| Product description | The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX I gene encodes a protein that is expressed in several tissues, including liver, kidney, testis, lung and nervous system. PRX II is expressed in testis, while PRX III shows expression in lung. PRX I, II and III are overexpressed in breast cancer and may be involved in its development or progression. Upregulated protein levels of PRX I and II in Alzheimer's disease (AD) and Down syndrome (DS) indicate the involvement of PRX I and II in their pathogenesis. The human PRX IV gene is abundantly expressed in many tissues. PRX IV exists as a precursor protein, which is only detected in testis, and a processed secreted form. PRX V also exists as two forms, designated long and short. Like PRX IV, the long form of PRX V is highly expressed in testis. The short form of PRX V is more widely expressed, with high expression in liver, kidney, heart and lung. PRX VI, a 1-Cys peroxiredoxin (also known as antioxidant protein 2 or AOP2), is highly expressed in most tissues, particularly in epithelial cells. Localized to the cell cytosol, PRX VI functions independently of other peroxiredoxins and antioxidant proteins, specializing in antioxidant defense, lung phospholipid metabolism and protection of keratinocytes from cell death induced by reactive oxygen species. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
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| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIPICC/IF |
| WB:1:500-1:2,000 ICC:1:50-1:200 IP:1:10-1:50 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | 1 Cys antibody 1 Cys peroxiredoxin antibody 1 Cys PRX antibody 1 cysPrx antibody 1-Cys peroxiredoxin antibody 1-Cys PRX antibody 24 kDa protein antibody 9430088D19Rik antibody AA690119 antibody Acidic calcium independent phospholipase A2 antibody Acidic calcium-independent phospholipase A2 antibody aiPLA2 antibody Antioxidant protein 2 antibody AOP2 antibody Aop2 rs3 antibody Brp 12 antibody Ciliary body glutathione peroxidase antibody CP 3 antibody EC 1.11.1.15 antibody EC 1.11.1.7 antibody EC 3.1.1. antibody Epididymis secretory sperm binding protein Li 128m antibody GPx antibody HEL S 128m antibody KIAA0106 antibody Liver 2D page spot 40 antibody Ltw4 antibody Lvtw 4 antibody MGC46173 antibody mKIAA0106 antibody Non selenium glutathione peroxidase antibody Non-selenium glutathione peroxidase antibody NSGPx antibody ORF06 antibody OTTHUMP00000032693 antibody p29 antibody Peroxiredoxin-6 antibody Peroxiredoxin6 antibody PHGPx antibody Phospholipase A2 lysosomal antibody PLA2 antibody PRDX 6 antibody Prdx5 antibody PRDX6 antibody Prdx6 rs3 antibody PRDX6_HUMAN antibody PRX antibody Red blood cells page spot 12 antibody Thiol specific antioxidant protein antibody |
|---|---|
| Molecular Weight(MW) | 25 kDa |
| Cellular Localization | Cytoplasm. Lysosome. |
Application
Fig1: Western blot analysis of PRDX6 on Jurkat cells lysates using anti-PRDX6 antibody at 1/500 dilution. Positive control： Line 1: Hela Line 2:HepG2| Positive Control | HepG2, Hela. |
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| Application Notes | WB:1:500-1:2,000 ICC:1:50-1:200 IP:1:10-1:50 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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