| 存储条件 |
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| Product Name | GAD67 [JM11-11] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 67 kDa glutamic acid decarboxylase antibody CPSQ1 antibody DCE1 antibody DCE1_HUMAN antibody EC 4.1.1.15 antibody FLJ45882 antibody GAD 67 antibody GAD antibody GAD-67 antibody GAD1 antibody Glutamate decarboxylase 1 (brain, 67kDa) antibody Glutamate decarboxylase 1 antibody Glutamate decarboxylase 1 brain 67kD antibody Glutamate decarboxylase 1 brain 67kDa antibody Glutamate decarboxylase 67 kDa isoform antibody Glutamate decarboxylase, brain, 67-KD antibody OTTHUMP00000041055 antibody SCP antibody |
| Product description | There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (g-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67, the predominant GAD-67 form and the minor GAD-25 form. GAD-25 is not expressed in brain but can be found in a variety of endocrine tissues. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIP |
| WB:1:500-1:1,000 IP:1:50-1:100 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | 67 kDa glutamic acid decarboxylase antibody CPSQ1 antibody DCE1 antibody DCE1_HUMAN antibody EC 4.1.1.15 antibody FLJ45882 antibody GAD 67 antibody GAD antibody GAD-67 antibody GAD1 antibody Glutamate decarboxylase 1 (brain 67kDa) antibody Glutamate decarboxylase 1 antibody Glutamate decarboxylase 1 brain 67kD antibody Glutamate decarboxylase 1 brain 67kDa antibody Glutamate decarboxylase 67 kDa isoform antibody Glutamate decarboxylase brain 67-KD antibody OTTHUMP00000041055 antibody SCP antibody |
|---|---|
| Molecular Weight(MW) | 67 kDa |
| Cellular Localization | Cytoplasm. |
Application
Fig1: Western blot analysis of GAD67 on Hela cells lysates using anti-GAD67 antibody at 1/500 dilution.| Positive Control | Hela. |
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| Application Notes | WB:1:500-1:1,000 IP:1:50-1:100 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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