| 存储条件 |
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| Product Name | Cyclophilin A [JM107-03] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Cyclophilin A antibody Cyclophilin antibody CyclophilinA antibody Cyclosporin A binding protein antibody Cyclosporin A-binding protein antibody CYPA antibody CYPH antibody Epididymis secretory sperm binding protein Li 69p antibody HEL S 69p antibody MGC117158 antibody MGC12404 antibody MGC23397 antibody Peptidyl prolyl cis trans isomerase A antibody Peptidyl-prolyl cis-trans isomerase A antibody Peptidylprolyl isomerase A (cyclophilin A) antibody Peptidylprolyl isomerase A antibody PPIA antibody PPIA protein antibody PPIA_HUMAN antibody PPIase A antibody Rotamase A antibody RotamaseA antibody T cell cyclophilin antibody |
| Product description | The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication. Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes (9,10). |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000-1:5,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | Cyclophilin A antibody Cyclophilin antibody CyclophilinA antibody Cyclosporin A binding protein antibody Cyclosporin A-binding protein antibody CYPA antibody CYPH antibody Epididymis secretory sperm binding protein Li 69p antibody HEL S 69p antibody MGC117158 antibody MGC12404 antibody MGC23397 antibody Peptidyl prolyl cis trans isomerase A antibody Peptidyl-prolyl cis-trans isomerase A antibody Peptidylprolyl isomerase A (cyclophilin A) antibody Peptidylprolyl isomerase A antibody PPIA antibody PPIA protein antibody PPIA_HUMAN antibody PPIase A antibody Rotamase A antibody RotamaseA antibody T cell cyclophilin antibody |
|---|---|
| Molecular Weight(MW) | 18 kDa |
| Cellular Localization | Cytoplasm, secreted. |
Application
Fig1: Western blot analysis of Cyclophilin A on different cells lysates using anti-Cyclophilin A antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: A431 Lane 3: HepG2
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin.| Positive Control | Hela, HepG2, A431, human breast carcinoma tissue, human lung tissue, human pancreas tissue, mouse lung tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:5,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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