| 存储条件 |
|---|
| Product Name | A2M [JM81-41] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | α-2-Macroglobulin (α-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, α-2M was characterized as a pan-proteinase inhibitor that was able to "bait" proteinases into cleaving specific peptide sequences on α-2M. This interaction induces a conformational change in α-2M, thus enabling it to "trap" the proteinase and further inhibit its activity. Subsequently, α-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor β (TGFβ) in serum is primarily bound to α-2M, which renders TGFβ inactive. α-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding α-2M are associated with an increased incidence of Alzheimer's Disease (AD), which is consistent with the role of α-2M in mediating the clearance and degradation of A β, the major component of β-Amyloid deposits accumulated during AD. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WB,IHC |
| WB:1:1,000-1:2,000 IHC:1:50-1:200 | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | A2m antibody A2MG_HUMAN antibody Alpha 2 M antibody Alpha 2M antibody Alpha-2-M antibody Alpha-2-macroglobulin antibody C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody CPAMD5 antibody DKFZp779B086 antibody FWP007 antibody S863 7 antibody |
|---|---|
| Molecular Weight(MW) | 163 kDa |
| Cellular Localization | Secreted. |
| SwissProt ID | P01023 |
|---|
Application
Fig1: Western blot analysis of A2M on human placenta cells lysates using anti-A2M antibody at 1/500 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- A2M antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti- A2M antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti- A2M antibody. Counter stained with hematoxylin.| Positive Control | Human placenta, human liver tissue, human tonsil tissue, human spleen tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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