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Product Profile
| Product Name | Integrin beta-1 [SR30-03] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | beta1 integrin antibody CD29 antibody Fibronectin receptor subunit beta antibody FNRB antibody Glycoprotein IIa antibody GP IIa antibody GPIIA antibody Integrin beta-1 antibody integrin VLA-4 beta subunit antibody Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) antibody ITB1_HUMAN antibody ITGB1 antibody MDF2 antibody MSK12 antibody OTTHUMP00000019420 antibody Very late activation protein, beta polypeptide antibody VLA BETA antibody VLA-4 subunit beta antibody VLA-BETA antibody VLAB antibody VLAbeta antibody |
| Product description | Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. |
| Immunogen | recombinant protein |
Key Feature
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCFC |
| WB:1:1,000-1:2,000 IHC:1:50-1:200: FC:1:50-1:100 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
Target Information
| Alternative Names | beta1 integrin antibody CD29 antibody Fibronectin receptor subunit beta antibody FNRB antibody Glycoprotein IIa antibody GP IIa antibody GPIIA antibody Integrin beta-1 antibody integrin VLA-4 beta subunit antibody Integrin beta 1 (fibronectin receptor beta polypeptide antigen CD29 includes MDF2 MSK12) antibody ITB1_HUMAN antibody ITGB1 antibody MDF2 antibody MSK12 antibody OTTHUMP00000019420 antibody Very late activation protein beta polypeptide antibody VLA BETA antibody VLA-4 subunit beta antibody VLA-BETA antibody VLAB antibody VLAbeta antibody |
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| Molecular Weight(MW) | 150 kDa |
| Cellular Localization | Cell membrane, Cell projection, Cleavage furrow |
Database Links
| SwissProt ID | P05556P09055P49134 |
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Application
Application
Fig1: Western blot analysis of Integrin beta-1 on human liver lysates using anti-Integrin beta-1 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Integrin beta-1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Integrin beta-1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Integrin beta-1 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti-Integrin beta-1 antibody. Counter stained with hematoxylin.
Application
Fig6: Flow cytometric analysis of Hela cells with Integrin beta-1 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
| Positive Control | Human liver tissue, human liver cancer tissue, human colon cancer tissue, mouse colon tissue, mouse stomach tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 IHC:1:50-1:200: FC:1:50-1:100 |
Additional Information
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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