| 存储条件 |
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Product Profile
| Product Name | Beta-Catenin [SA30-04] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Beta catenin antibody Beta-catenin antibody Cadherin associated protein antibody Catenin (cadherin associated protein), beta 1, 88kDa antibody Catenin beta 1 antibody Catenin beta-1 antibody CATNB antibody CHBCAT antibody CTNB1_HUMAN antibody CTNNB antibody CTNNB1 antibody DKFZp686D02253 antibody FLJ25606 antibody FLJ37923 antibody OTTHUMP00000162082 antibody OTTHUMP00000165222 antibody OTTHUMP00000165223 antibody OTTHUMP00000209288 antibody OTTHUMP00000209289 antibody |
| Product description | β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines. |
| Immunogen | recombinant protein |
Key Feature
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICCIHCIP |
| WB:1:500-1:5,000 ICC | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
Target Information
| Alternative Names | Beta catenin antibody Beta-catenin antibody Cadherin associated protein antibody Catenin (cadherin associated protein) beta 1 88kDa antibody Catenin beta 1 antibody Catenin beta-1 antibody CATNB antibody CHBCAT antibody CTNB1_HUMAN antibody CTNNB antibody CTNNB1 antibody DKFZp686D02253 antibody FLJ25606 antibody FLJ37923 antibody OTTHUMP00000162082 antibody OTTHUMP00000165222 antibody OTTHUMP00000165223 antibody OTTHUMP00000209288 antibody OTTHUMP00000209289 antibody |
|---|---|
| Molecular Weight(MW) | 92 kDa |
| Cellular Localization | Cytoplasm, Nucleus, Cell membrane, Cell junction |
Database Links
| SwissProt ID | P35222Q02248Q9WU82 |
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Application
Application
Fig1: Western blot analysis of Beta-Catenin on different cell lysates using anti- Beta-Catenin antibody at 1/1,000 dilution.Positive control:Lane 1: SW480Lane 2: HT29Lane 3: A431
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti- Beta-Catenin antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti- Beta-Catenin antibody. Counter stained with hematoxylin.
| Positive Control | SW480, HT29, A431, HepG2, human colon cancer tissue, mouse colon tissue. |
|---|---|
| Application Notes | WB:1:500-1:5,000 ICC |
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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