| 存储条件 |
|---|
| Product Name | XRCC1 [JA11-47] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DNA repair protein XRCC1 antibody RCC antibody X ray repair complementing defective repair in chinese hamster antibody X ray Repair Complementing Defective Repair in Chinese Hamster Cells antibody X ray repair complementing defective repair in chinese hamster cells 1 antibody X ray repair cross complementing 1 antibody X ray repair cross complementing protein 1 antibody X ray repair, complementing defective, repair in Chinese hamster antibody X ray repair cross-complementing protein 1 antibody XRCC 1 antibody Xrcc1 antibody XRCC1_HUMAN antibody |
| Product description | The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad5. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | DNA repair protein XRCC1 antibody RCC antibody X ray repair complementing defective repair in chinese hamster antibody X ray Repair Complementing Defective Repair in Chinese Hamster Cells antibody X ray repair complementing defective repair in chinese hamster cells 1 antibody X ray repair cross complementing 1 antibody X ray repair cross complementing protein 1 antibody X ray repair complementing defective repair in Chinese hamster antibody X ray repair cross-complementing protein 1 antibody XRCC 1 antibody Xrcc1 antibody XRCC1_HUMAN antibody |
|---|---|
| Molecular Weight(MW) | 100/70 kDa |
| Cellular Localization | Nucleus. |
Application
Fig1: Western blot analysis of XRCC1 on different cells lysates using anti-XRCC1 antibody at 1/500 dilution. Positive control: Line 1: Hela Line 2: 293T Line 3: Jarkat
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti- XRCC1 antibody. Counter stained with hematoxylin.| Positive Control | Jurkat, 293T, Hela, mouse testis tissue. |
|---|---|
| Application Notes | WB:1:500-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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