| 存储条件 |
|---|
| Product Name | Mre11 [JM11-18] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AT like disease antibody Ataxia telangiectasia disorder like antibody ATLD antibody DNA recombination and repair protein antibody Double strand break repair protein MRE11A antibody Double-strand break repair protein MRE11A antibody endo/exonuclease Mre11 antibody HNGS1 antibody meiotic recombination (S. cerevisiae) 11 homolog A antibody Meiotic recombination 11 homolog 1 antibody meiotic recombination 11 homolog A (S. cerevisiae) antibody Meiotic recombination 11 homolog A antibody MmMRE11A antibody Mre 11 antibody MRE 11a antibody MRE 11b antibody MRE11 homolog 1 antibody MRE11 homolog A antibody MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody MRE11 meiotic recombination 11 homolog A antibody MRE11_HUMAN antibody MRE11A antibody MRE11b antibody OTTHUMP00000236830 antibody OTTHUMP00000236831 antibody OTTHUMP00000236832 antibody OTTHUMP00000236833 antibody |
| Product description | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:1,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | AT like disease antibody Ataxia telangiectasia disorder like antibody ATLD antibody DNA recombination and repair protein antibody Double strand break repair protein MRE11A antibody Double-strand break repair protein MRE11A antibody endo/exonuclease Mre11 antibody HNGS1 antibody meiotic recombination (S. cerevisiae) 11 homolog A antibody Meiotic recombination 11 homolog 1 antibody meiotic recombination 11 homolog A (S. cerevisiae) antibody Meiotic recombination 11 homolog A antibody MmMRE11A antibody Mre 11 antibody MRE 11a antibody MRE 11b antibody MRE11 homolog 1 antibody MRE11 homolog A antibody MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody MRE11 meiotic recombination 11 homolog A antibody MRE11_HUMAN antibody MRE11A antibody MRE11b antibody OTTHUMP00000236830 antibody OTTHUMP00000236831 antibody OTTHUMP00000236832 antibody OTTHUMP00000236833 antibody |
|---|---|
| Molecular Weight(MW) | 81 kDa |
| Cellular Localization | Nucleus. |
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti- Mre11 antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti- Mre11 antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti- Mre11 antibody. Counter stained with hematoxylin.| Positive Control | 293T, Hela, human breast cancer tissue, human stomach cancer tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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