| 存储条件 |
|---|
| Product Name | Urokinase [JM106-09] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Urokinase plasminogen activator receptor (uPAR), also designated CD87, is a glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum b-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a Trypsin- like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. This pathway is observed during re-epithelialization of lesions, wound healing and tissue remodeling. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial origin tumor cells and are required for tumor invasion and metastasis. Ras, MEK, ERK and MLCK function as downstream effectors in the uPAR-dependent signaling cascade, which is initiated by uPA binding, and promotes cellular migration in an integrin selective manner. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WB,IHC |
| WB:1:1,000-1:5,000 IHC:1:50-1:200 | |
| Species Reactivity | Human,Mouse,Rat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | ATF antibody ATF uPA antibody BDPLT5 antibody Plasminogen activator antibody Plasminogen activator urinary antibody Plasminogen activator urokinase antibody PLAU antibody QPD antibody u PA antibody U plasminogen activator antibody u-PA antibody U-plasminogen activator antibody uPA antibody URK antibody UROK_HUMAN antibody Urokinase plasminogen activator antibody Urokinase type plasminogen activator antibody Urokinase type plasminogen activator precursor antibody Urokinase-type plasminogen activator chain B antibody |
|---|---|
| Molecular Weight(MW) | 49 kDa |
| Cellular Localization | Secreted. |
Application
Fig1: Western blot analysis of Urokinase on MCF-7 cells lysates using anti-Urokinase antibody at 1/500 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissue using anti-Urokinase antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using anti-Urokinase antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Urokinase antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Urokinase antibody. Counter stained with hematoxylin.| Positive Control | MCF-7, human liver carcinoma tissue, human colon carcinoma, human kidney tissue, mouse kidney tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:5,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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