| 存储条件 |
|---|
| Product Name | Laminin beta 1 [JM099-03] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CLM antibody Cutis laxa with marfanoid phenotype antibody LAM B1 antibody LAMB 1 antibody LAMB1 antibody LAMB1_HUMAN antibody Laminin B1 antibody Laminin B1 chain antibody Laminin beta 1 chain antibody Laminin beta 1 chain precursor antibody Laminin beta1 antibody Laminin subunit beta 1 antibody Laminin subunit beta-1 antibody Laminin-1 subunit beta antibody Laminin-10 subunit beta antibody Laminin-12 subunit beta antibody Laminin-2 subunit beta antibody Laminin-6 subunit beta antibody Laminin-8 subunit beta antibody LIS5 antibody MGC142015 antibody |
| Product description | Laminins are essential and abundant structural non-collagenous glyco- proteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of laminins with stabilizing type IV collagen networks, nidogen, and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve, and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression, and tissue architecture. Each laminin is a heterotrimer of a, b, and g chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and cognate laminin receptors. The human Laminin b-1 gene maps to chromosome 7q22 and is ubiquitously expressed in tissues that produce basement membranes. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCFC |
| WB:1:1,000 FC:1:50-1:100 IHC:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | CLM antibody Cutis laxa with marfanoid phenotype antibody LAM B1 antibody LAMB 1 antibody LAMB1 antibody LAMB1_HUMAN antibody Laminin B1 antibody Laminin B1 chain antibody Laminin beta 1 chain antibody Laminin beta 1 chain precursor antibody Laminin beta1 antibody Laminin subunit beta 1 antibody Laminin subunit beta-1 antibody Laminin-1 subunit beta antibody Laminin-10 subunit beta antibody Laminin-12 subunit beta antibody Laminin-2 subunit beta antibody Laminin-6 subunit beta antibody Laminin-8 subunit beta antibody LIS5 antibody MGC142015 antibody |
|---|---|
| Molecular Weight(MW) | 198 kDa |
| Cellular Localization | Secreted. |
Application
Fig1: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Laminin beta 1 antibody. Counter stained with hematoxylin.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Laminin beta 1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse prostate tissue using anti-Laminin beta 1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Laminin beta 1 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue using anti-Laminin beta 1 antibody. Counter stained with hematoxylin.
Application
Fig6: Flow cytometric analysis of A431 cells with Laminin beta 1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the s?皪?皫??皩?羉瘍%?| Positive Control | A431, human kidney tissue, mouse colon tissue, mouse prostate tissue, mouse kidney tissue, mouse small intestine tissue. |
|---|---|
| Application Notes | WB:1:1,000 FC:1:50-1:100 IHC:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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