3 hydroxy 3 methylglutaryl CoA reductase antibody 3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody 3 hydroxymethylglutaryl CoA reductase antibody 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody 3H3M antibody HMDH_HUMAN antibody HMG CoA reductase antibody HMG CoAR antibody HMG-CoA reductase antibody Hmgcr antibody Hydroxymethylglutaryl CoA reductase antibody LDLCQ3 antibody MGC103269 antibody Red antibody
Product description
The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBIP
WB:1:1,000-1:2,000
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Target Information
Alternative Names
3 hydroxy 3 methylglutaryl CoA reductase antibody 3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody 3 hydroxymethylglutaryl CoA reductase antibody 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody 3H3M antibody HMDH_HUMAN antibody HMG CoA reductase antibody HMG CoAR antibody HMG-CoA reductase antibody Hmgcr antibody Hydroxymethylglutaryl CoA reductase antibody LDLCQ3 antibody MGC103269 antibody Red antibody
