| 存储条件 |
|---|
| Product Name | STAT2 [JF0884] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Homo sapiens interferon alpha induced transcriptional activator antibody interferon alpha induced transcriptional activator antibody ISGF 3 antibody ISGF3 antibody MGC59816 antibody P113 antibody signal transducer and activator of transcription 2 113kD antibody Signal transducer and activator of transcription 2 antibody STAT113 antibody Stat2 antibody STAT2_HUMAN antibody |
| Product description | Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICCIHC |
| WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | Homo sapiens interferon alpha induced transcriptional activator antibody interferon alpha induced transcriptional activator antibody ISGF 3 antibody ISGF3 antibody MGC59816 antibody P113 antibody signal transducer and activator of transcription 2 113kD antibody Signal transducer and activator of transcription 2 antibody STAT113 antibody Stat2 antibody STAT2_HUMAN antibody |
|---|---|
| Molecular Weight(MW) | 98 kDa |
| Cellular Localization | Cytoplasm, Nucleus. |
Application
Fig1: ICC staining STAT2 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig2: ICC staining STAT2 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining STAT2 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-STAT2 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-STAT2 antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-STAT2 antibody. Counter stained with hematoxylin.| Positive Control | A431, A549, SW480, human lung cancer tissue, human colon cancer tissue, mouse skin tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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