| 存储条件 |
|---|
| Product Name | FGFR1 [SD08-25] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Basic fibroblast growth factor receptor 1 antibody bFGF-R-1 antibody BFGFR antibody CD331 antibody CEK antibody FGFBR antibody FGFR 1 antibody FGFR-1 antibody FGFR1 antibody FGFR1/PLAG1 fusion antibody FGFR1_HUMAN antibody fibroblast growth factor receptor 1 antibody FLG antibody FLT-2 antibody FLT2 antibody Fms-like gene antibody Fms-like tyrosine kinase 2 antibody fms-related tyrosine kinase 2 antibody HBGFR antibody heparin-binding growth factor receptor antibody HH2 antibody HRTFDS antibody hydroxyaryl-protein kinase antibody KAL2 antibody N-SAM antibody OGD antibody Proto-oncogene c-Fgr antibody |
| Product description | Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor (FGFR-1), the Bek receptor (FGFR-2), FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Flg maps to chromosome 8p12 and is alternatively spliced to produce several isoforms. Mutations in Flg are associated with Pfeiffer syndrome (a skeletal disorder characterized by craniosynostosis with deviation and enlargement of the thumbs and great toes), brachymesophalangy with phalangeal ankylosis and a varying degree of soft tissue syndactyly. The Flg gene is also involved in chromosomal translocations with ZNF198, CEP110 and FOP, which may lead to stem cell leukemia lymphoma (SCLL). |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IF |
| WB:1:1,000 ICC:1:50-1:100 | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Basic fibroblast growth factor receptor 1 antibody bFGF-R-1 antibody BFGFR antibody CD331 antibody CEK antibody FGFBR antibody FGFR 1 antibody FGFR-1 antibody FGFR1 antibody FGFR1/PLAG1 fusion antibody FGFR1_HUMAN antibody fibroblast growth factor receptor 1 antibody FLG antibody FLT-2 antibody FLT2 antibody Fms-like gene antibody Fms-like tyrosine kinase 2 antibody fms-related tyrosine kinase 2 antibody HBGFR antibody heparin-binding growth factor receptor antibody HH2 antibody HRTFDS antibody hydroxyaryl-protein kinase antibody KAL2 antibody N-SAM antibody OGD antibody Proto-oncogene c-Fgr antibody |
|---|---|
| Molecular Weight(MW) | 100,140 kDa |
| Cellular Localization | Cell membrane, Nucleus, Cytoplasm. |
| SwissProt ID | P11362 |
|---|
Application
Fig1: Western blot analysis of FGFR1 on 293 cells lysates using anti-FGFR1 antibody at 1/1,000 dilution.
Application
Fig2: ICC staining FGFR1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining FGFR1 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Positive Control | 293, 293T, Hela. |
|---|---|
| Application Notes | WB:1:1,000 ICC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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