| 存储条件 |
|---|
| Product Name | NACC1 [D1-H2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BEND8 antibody BTB Domain Containing 14B antibody BTB/POZ domain-containing protein 14B antibody btbd14b antibody FLJ37383 antibody NAC-1 antibody NAC1 antibody Nacc1 antibody NACC1_HUMAN antibody Nucleus accumbens-associated protein 1 antibody |
| Product description | The BTB (broad-complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. BTBD14B (BTB/POZ domain-containing protein 14B), also known as NACC1 (nucleus accumbens associated 1), BEND8 or NAC1, is a 527 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one BTB (POZ) domain. Existing as a homooligomer that interacts with HDAC3 and HDAC4, BTBD14B functions as a transcriptional repressor that influences the transcriptional activity of CRIF1 and is required for proteasome recruitment to the nucleus and cytoplasm in dendritic spines. BTBD14B is overexpressed in multiple carcinomas, suggesting a role in tumor development and metastasis. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:500-1:1,000 IHC:1:100-1:500 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Purification | Unpurified |
| Alternative Names | BEND8 antibody BTB Domain Containing 14B antibody BTB/POZ domain-containing protein 14B antibody btbd14b antibody FLJ37383 antibody NAC-1 antibody NAC1 antibody Nacc1 antibody NACC1_HUMAN antibody Nucleus accumbens-associated protein 1 antibody |
|---|---|
| Molecular Weight(MW) | 58 kDa |
| Cellular Localization | Nucleus. Cytoplasm. |
| SwissProt ID | Q96RE7 |
|---|
Application
Fig1: Western blot analysis of NACC1 on HEK293 (1) and NACC1-hIgGFc transfected HEK293 (2) cell lysate using anti-NACC1 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human mammary cancer tissue using anti-NACC1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-NACC1 antibody. Counter stained with hematoxylin.| Positive Control | NACC1-hIgGFc transfected HEK293 cell lysate, human mammary cancer tissue, human ovarian cancer tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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