| 存储条件 |
|---|
| Product Name | BAG1 [F11-A7] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Bag 1 antibody BAG family molecular chaperone regulator 1 antibody BAG-1 antibody BAG1 antibody BAG1_HUMAN antibody BCL 2 Associated Athanogene 1 antibody BCL 2 associated athanogene antibody BCL 2 binding athanogene 1 antibody Bcl-2-associated athanogene 1 antibody BCL2 associated athanogene 1 antibody BCL2 associated athanogene antibody Glucocorticoid receptor-associated protein RAP46 antibody HAP1 antibody Haptoglobin antibody RAP 46 antibody RAP46 antibody |
| Product description | The Bcl-2 family of proteins is characterized by its ability to modulate cell death (apoptosis) under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis, while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. For instance, Bcl-xL represses cell death, while its shorter form, Bcl-xS, promotes apoptosis. Dimerization of another member of this family, Bad, with Bcl-xL, results in displacement of Bax from Bcl-xL/Bax complexes and restoration of Bax-mediated apoptosis. A Bcl-2-binding protein, designated Bag-1, lacks significant homology with Bcl-2 or with other Bcl-2-related proteins. Bag-1 appears to function to enhance Bcl-2 protection from cell death, suggesting that Bag-1 represents a new type of anti-cell death gene. This also suggests that certain routes of apoptosis induction, previously ascribed to Bcl-2-independent pathways, may instead reflect a requirement for a combination of Bcl-2 and Bag-1. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB:1:500-1:2,000 FC:1:50-1:100 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Bag 1 antibody BAG family molecular chaperone regulator 1 antibody BAG-1 antibody BAG1 antibody BAG1_HUMAN antibody BCL 2 Associated Athanogene 1 antibody BCL 2 associated athanogene antibody BCL 2 binding athanogene 1 antibody Bcl-2-associated athanogene 1 antibody BCL2 associated athanogene 1 antibody BCL2 associated athanogene antibody Glucocorticoid receptor-associated protein RAP46 antibody HAP1 antibody Haptoglobin antibody RAP 46 antibody RAP46 antibody |
|---|---|
| Molecular Weight(MW) | 39 kDa |
| Cellular Localization | Cytoplasm. Nucleus |
| SwissProt ID | Q99933 |
|---|
Application
Fig1: Western blot analysis of BAG1 on human BAG1 recombinant protein using anti-BAG1 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of BAG1 on HEK293 (1) and BAG1-hIgGFc transfected HEK293 (2) cell lysate using anti-BAG1 antibody at 1/1,000 dilution.
Application
Fig3: Flow cytometric analysis of Hela cells with BAG1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human BAG1 recombinant protein, BAG1-hIgGFc transfected HEK293 cell lysate, Hela. |
|---|---|
| Application Notes | WB:1:500-1:2,000 FC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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