| 存储条件 |
|---|
| Product Name | TLR5 [JM10-88] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FLJ10052 antibody MGC126430 antibody MGC126431 antibody SLEB1 antibody TIL 3 antibody TIL3 antibody TLR 5 antibody Tlr5 antibody TLR5_HUMAN antibody Toll like receptor 5 antibody Toll like receptor 5 precursor antibody Toll-like receptor 5 antibody Toll/interleukin 1 receptor like protein 3 antibody Toll/interleukin-1 receptor-like protein 3 antibody |
| Product description | Six human homologs of the Drosophila Toll receptor were initially identified based on their sequence similarities and designated toll-like receptors (TLR). Toll receptors are involved in mediating dorsoventral polarization in the developing Drosophila embryo and also participate in the host immunity. The TLR family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFkB and suggests that these receptors are involved in mediating inflammatory responses. TLR5 specifically participates in the innate immune response to microbial agents. TLR5 is highly expressed in ovary and in peripheral blood leukocytes, most abundantly in monocytes and, to a lesser extent, in prostate and testis. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000-1:2,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | FLJ10052 antibody MGC126430 antibody MGC126431 antibody SLEB1 antibody TIL 3 antibody TIL3 antibody TLR 5 antibody Tlr5 antibody TLR5_HUMAN antibody Toll like receptor 5 antibody Toll like receptor 5 precursor antibody Toll-like receptor 5 antibody Toll/interleukin 1 receptor like protein 3 antibody Toll/interleukin-1 receptor-like protein 3 antibody |
|---|---|
| Molecular Weight(MW) | 97 kDa |
| Cellular Localization | Membrane. |
Application
Fig1: Western blot analysis of TLR5 on Hela cells lysates using anti-TLR5 antibody at 1/500 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-TLR5 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse prostate tissue using anti-TLR5 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse stomack tissue using anti-TLR5 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-TLR5 antibody. Counter stained with hematoxylin.| Positive Control | Hela, human liver tissue, human spleen tissue, mouse testis tissue, mouse prostate tissue, mouse stomack tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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