CD107 antigen like family member A antibody CD107 antigen-like family member A antibody CD107a antibody CD107a antigen antibody LAMP 1 antibody LAMP-1 antibody LAMP1 antibody LAMP1_HUMAN antibody LAMPA antibody LGP120 antibody lgpA antibody Lysosomal membrane glycoprotein 120KD antibody Lysosomal Associated Membrane Protein 1 antibody Lysosome associated membrane glycoprotein 1 antibody Lysosome-associated membrane glycoprotein 1 antibody Lysosome-associated membrane protein 1 antibody OTTHUMP00000040663 antibody
Product description
Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107a) and LAMP-2 (also designated CD107b) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans-Golgi network and are transported intracellularly via a pathway that is distinct from the Clathrin-coated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of Thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBIHC
WB:1:1,000-1:2,000 IHC:1:50-1:200
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Alternative Names
CD107 antigen like family member A antibody CD107 antigen-like family member A antibody CD107a antibody CD107a antigen antibody LAMP 1 antibody LAMP-1 antibody LAMP1 antibody LAMP1_HUMAN antibody LAMPA antibody LGP120 antibody lgpA antibody Lysosomal membrane glycoprotein 120KD antibody Lysosomal Associated Membrane Protein 1 antibody Lysosome associated membrane glycoprotein 1 antibody Lysosome-associated membrane glycoprotein 1 antibody Lysosome-associated membrane protein 1 antibody OTTHUMP00000040663 antibody
Molecular Weight(MW)
120 kDa
Cellular Localization
Cell membrane, Endosome membrane, Lysosome membrane, Late endosome.
