Coagulation factor VIII antibody Coagulation factor VIII VWF antibody F8VWF antibody Factor VIII related antigen antibody von Willebrand antigen 2 antibody von Willebrand antigen II antibody Von Willebrand disease antibody VWD antibody vWF antibody VWF_HUMAN antibody
Product description
Von Willebrand disease is a congenital bleeding disorder caused by defects in the von Willebrand factor protein (VWF). VWF is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets, and it is involved in the coagulation of blood at injury sites. VWF acts as a carrier protein for Factor VIII, a cofactor required for coagulation, and it promotes platelet adhesion and aggregation. Several factors are known to stimulate the binding of VWF to platelets, including glycoprotein 1b, ristocetin, botrocetin, collagen, sulphatides and heparin. Of the several domains contained within VWF, the A1, A2 and A3 domains have been shown to mediate this activation. VWF is thought to undergo a variety of posttranslational modifications that influence the affinity and availability for Factor VII, including cleavage of the propeptide and formation of N-terminal intersubunit disulfide bonds.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBIHC
WB:1:1,000-1:5,000 IHC:1:50-1:200
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Alternative Names
Coagulation factor VIII antibody Coagulation factor VIII VWF antibody F8VWF antibody Factor VIII related antigen antibody von Willebrand antigen 2 antibody von Willebrand antigen II antibody Von Willebrand disease antibody VWD antibody vWF antibody VWF_HUMAN antibody
Fig1: Western blot analysis of Von Willebrand Factor on human lung lysates using anti-Von Willebrand Factor antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Von Willebrand Factor antibody. Counter stained with hematoxylin.
Positive Control
Human tonsil tissue, human lung tissue.
Application Notes
WB:1:1,000-1:5,000 IHC:1:50-1:200
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
