| 存储条件 |
|---|
| Product Name | mGluR2 [JJ091-09] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AMPA selective glutamate receptor 2 antibody GLUR2 antibody GLURB antibody Glutamate metabotropic receptor 2 antibody Glutamate receptor homolog antibody Glutamate receptor metabotropic 2 antibody GPRC1B antibody GRM2 antibody GRM2_HUMAN antibody Metabotropic glutamate receptor 2 antibody mGlu2 antibody mGluR2 antibody OTTHUMP00000210984 antibody OTTHUMP00000210986 antibody |
| Product description | The mGluR proteins (metabotropic glutamate receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-2, which may interact with GRASP, acts as a receptor for glutamate. It may also be involved in the regulation of neurotransmission suppression and in synaptogenesis or synaptic stablization. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IFIHC |
| WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | AMPA selective glutamate receptor 2 antibody GLUR2 antibody GLURB antibody Glutamate metabotropic receptor 2 antibody Glutamate receptor homolog antibody Glutamate receptor metabotropic 2 antibody GPRC1B antibody GRM2 antibody GRM2_HUMAN antibody Metabotropic glutamate receptor 2 antibody mGlu2 antibody mGluR2 antibody OTTHUMP00000210984 antibody OTTHUMP00000210986 antibody |
|---|---|
| Molecular Weight(MW) | 96 kDa |
| Cellular Localization | Cell membrane, Cell junction, Cell projection. |
Application
Fig1: ICC staining mGluR2 in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig2: ICC staining mGluR2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining mGluR2 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-mGluR2 antibody. Counter stained with hematoxylin.| Positive Control | SH-SY-5Y, SW480, Hela, mouse brain tissue. |
|---|---|
| Application Notes | WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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