Brain 2 antibody Brain specific homeobox/POU domain protein 2 antibody Brain-2 antibodyBrain-specific homeobox/POU domain protein 2 antibody BRN 2 antibody Brn-2 antibody BRN2 antibody N Oct 3 antibody N OCT 3 Gene antibody N Oct3 antibody Nervous system specific octamer binding transcription factor antibody Nervous system-specific octamer-binding transcription factor N-Oct-3 antibody OCT 7 antibody Oct-7 antibody OCT7 antibody Octamer Binding Transcription Factor 7 antibody Octamer-binding protein 7 antibody Octamer-binding transcription factor 7 antibody OTF 7 antibody OTF-7 antibody OTF7 antibody PO3F2_HUMAN antibody POU class 3 homeobox 2, antibody POU domain class 3 transcription factor 2 antibody POU domain, class 3, transcription factor 2 antibody Pou3f2 antibody POUF 3 antibody POUF3 antibody Protein Brn 2 antibody
Product description
The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU domain proteins. Expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons, Brn-1 and Brn-2 appear to critically control the initiation of radial migration of cortical neurons. Brn-2 is thought to be involved in smooth muscle cell development and differentiation. Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. Brn-3a has two functional transactivating domains, one at the amino terminus and one at the carboxy terminus. While Brn-3a and Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor.
Immunogen
Recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Host Species
Mouse
Tested Applications
WB
WB:1:500-1:2,000
Species Reactivity
Human
Concentration
2mg/ml
Purification
Unpurified
Target Information
Alternative Names
Brain 2 antibody Brain specific homeobox/POU domain protein 2 antibody Brain-2 antibodyBrain-specific homeobox/POU domain protein 2 antibody BRN 2 antibody Brn-2 antibody BRN2 antibody N Oct 3 antibody N OCT 3 Gene antibody N Oct3 antibody Nervous system specific octamer binding transcription factor antibody Nervous system-specific octamer-binding transcription factor N-Oct-3 antibody OCT 7 antibody Oct-7 antibody OCT7 antibody Octamer Binding Transcription Factor 7 antibody Octamer-binding protein 7 antibody Octamer-binding transcription factor 7 antibody OTF 7 antibody OTF-7 antibody OTF7 antibody PO3F2_HUMAN antibody POU class 3 homeobox 2 antibody POU domain class 3 transcription factor 2 antibody POU domain class 3 transcription factor 2 antibody Pou3f2 antibody POUF 3 antibody POUF3 antibody Protein Brn 2 antibody
