| 存储条件 |
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| Product Name | Endothelin B Receptor [JM74-10] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ABCDS antibody Ednra antibody EDNRB antibody EDNRB_HUMAN antibody Endothelin B receptor antibody Endothelin B receptor precursor antibody Endothelin receptor Non selective type antibody Endothelin receptor non-selective type antibody Endothelin receptor type B antibody ET B antibody ET-B antibody ET-BR antibody ETB antibody ETBR antibody ETRB antibody Hirschsprung disease 2 antibody HSCR antibody HSCR2 antibody OTTHUMP00000018534 antibody OTTHUMP00000178736 antibody WS4A antibody |
| Product description | Endothelin receptor B (ETBR), also known as EDNRB, ETB, ETRB, HSCR and HSCR2, is a member of the guanine-binding, regulatory protein-coupled receptor family. Three isoforms of ETBR exist called isoform 1, isoform 2 and δ 3. ETBR is involved in the regulation of sodium excretion and glomular filtration rate (GFR). ETBR plays a role in the normal development of the neural crestderived cell lineages, epidermal melanocytes and enteric neurons. ETBR is expressed in lung, kidney, placenta, skeletal muscle and stem villi vessels. Both of the ET receptors, ETAR and ETBR, are activated by ET1, which results in inhibition of active lens sodium-potassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cultured lens epithelial cells. ETBR deficiency causes early onset dysfunction of the kidney, characterized by reduced sodium excretion, decreased GFR and slightly elevated blood pressure. Mutations in the gene encoding ETBR produce congenital aganglionic megacolon and pigment abnormalities. The multigenic disorder, Hirschsprung’s disease type 2, is also due to a mutation in the ETBR gene. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIP |
| WB:1:500-1:2,000 IP:1:10-1:50 | |
| Species Reactivity | HumanZebra Fish |
| Concentration | 1mg/ml |
| Alternative Names | ABCDS antibody Ednra antibody EDNRB antibody EDNRB_HUMAN antibody Endothelin B receptor antibody Endothelin B receptor precursor antibody Endothelin receptor Non selective type antibody Endothelin receptor non-selective type antibody Endothelin receptor type B antibody ET B antibody ET-B antibody ET-BR antibody ETB antibody ETBR antibody ETRB antibody Hirschsprung disease 2 antibody HSCR antibody HSCR2 antibody OTTHUMP00000018534 antibody OTTHUMP00000178736 antibody WS4A antibody |
|---|---|
| Molecular Weight(MW) | 50 kDa |
| Cellular Localization | Cell membrane. |
| SwissProt ID | P24530 |
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Application
Fig1: Western blot analysis of Endothelin B Receptor on different cells lysates using anti-Endothelin B Receptor antibody at 1/500 dilution. Positive control: Lane 1: Zebrafish Lane 2: Raji Line 3: JAR| Positive Control | JAR, Raji. |
|---|---|
| Application Notes | WB:1:500-1:2,000 IP:1:10-1:50 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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