c MER antibody c mer proto oncogene tyrosine kinase antibody c-mer antibody cMER antibody cmer protooncogene tyrosine kinase antibody Eyk antibody MER antibody MER receptor tyrosine kinase antibody MERK antibody MERPEN antibody Mertk antibody MERTK c-mer proto-oncogene tyrosine kinase antibody MERTK_HUMAN antibody MGC133349 antibody nmf12 antibody Nyk antibody Proto oncogene tyrosine protein kinase MER antibody Proto oncogene tyrosine protein kinase MER precursor antibody Proto-oncogene c-Mer antibody Receptor tyrosine kinase MerTK antibody RP38 antibody STK kinase antibody Tyrosine-protein kinase Mer antibody
Product description
MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulin-like C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2 (PI-PLC 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBIHCIP
WB:1:1,000-1:2,000 IHC:1:50-1:200
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Alternative Names
c MER antibody c mer proto oncogene tyrosine kinase antibody c-mer antibody cMER antibody cmer protooncogene tyrosine kinase antibody Eyk antibody MER antibody MER receptor tyrosine kinase antibody MERK antibody MERPEN antibody Mertk antibody MERTK c-mer proto-oncogene tyrosine kinase antibody MERTK_HUMAN antibody MGC133349 antibody nmf12 antibody Nyk antibody Proto oncogene tyrosine protein kinase MER antibody Proto oncogene tyrosine protein kinase MER precursor antibody Proto-oncogene c-Mer antibody Receptor tyrosine kinase MerTK antibody RP38 antibody STK kinase antibody Tyrosine-protein kinase Mer antibody
