| 存储条件 |
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Product Profile
| Product Name | Netrin receptor DCC |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Colorectal cancer related chromosome sequence 18 antibody Colorectal cancer suppressor antibody CRC 18 antibody CRC18 antibody CRCR 1 antibody CRCR1 antibody DCC antibody DCC_HUMAN antibody Deleted in colorectal cancer protein antibody Deleted in colorectal carcinoma antibody Immunoglobulin superfamily DCC subclass member 1 antibody Netrin receptor DCC antibody Tumor suppressor protein DCC antibody |
| Product description | Netrin receptor DCC (deleted colorectal careinoma) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas. |
| Immunogen | recombinant protein |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICCIHCFC |
| WB:1:500-1:1,000 | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
Target Information
| Alternative Names | Colorectal cancer related chromosome sequence 18 antibody Colorectal cancer suppressor antibody CRC 18 antibody CRC18 antibody CRCR 1 antibody CRCR1 antibody DCC antibody DCC_HUMAN antibody Deleted in colorectal cancer protein antibody Deleted in colorectal carcinoma antibody Immunoglobulin superfamily DCC subclass member 1 antibody Netrin receptor DCC antibody Tumor suppressor protein DCC antibody |
|---|---|
| Molecular Weight(MW) | 90 kDa |
| Cellular Localization | Cell membrane |
Database Links
| SwissProt ID | P43146 |
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Application
Application
Fig1: Western blot analysis on Hela using anti- Netrin receptor DCC polyclonal antibody
| Positive Control | Human brain, mouse brain |
|---|---|
| Application Notes | WB:1:500-1:1,000 |
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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