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Product Profile
| Product Name | Autoimmune regulator |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AIRE antibody AIRE_HUMAN antibody AIRE1 antibody APECED antibody APECED protein antibody APS1 antibody APSI antibody Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody Autoimmune regulator antibody Autoimmune regulator protein antibody PGA1 antibody |
| Product description | The Autoimmune Regulator (AIRE) is a human transcription factor expressed at higher level in thymus, pancreas, adrenal cortex, and testis. It is expressed at lower level in the spleen, fetal liver and lymph nodes. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. In the thymus it causes transcription of a wide selection of organ-specific genes which create proteins that are usually only expressed in peripheral tissues, creating an "immunological self-shadow" in the thymus. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type I (APS-1). |
| Immunogen | peptide |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICCIHC |
| WB:1:2,000 ICC:1:500 IHC:1:100 | |
| Species Reactivity | Mouse |
| Concentration | 1mg/ml |
Target Information
| Alternative Names | AIRE antibody AIRE_HUMAN antibody AIRE1 antibody APECED antibody APECED protein antibody APS1 antibody APSI antibody Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody Autoimmune regulator antibody Autoimmune regulator protein antibody PGA1 antibody |
|---|---|
| Molecular Weight(MW) | 59 kDa |
| Cellular Localization | Cell nuclear, cytoplasm |
Database Links
| SwissProt ID | Q9Z0E3 |
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Application
Application
Fig1: Western blot analysis on 293 cell (A) transfected and (B) none transfected with AIRE gene using anti-AIRE polyclonal antibody.
Application
Fig2: Immunohistochemistry- staining AIRE in mouse thymus by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.
Application
Fig3: AIRE staining (red) in mouse embryonic stem cells (D3) by immunocytochemistry, nuclear staining with DAPI (blue) and SSEA-1 staining (green).
| Positive Control | Transfected 293 cells |
|---|---|
| Application Notes | WB:1:2,000 ICC:1:500 IHC:1:100 |
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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