| 存储条件 |
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Product Profile
| Product Name | Integrin alpha 6 [SR45-00] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Alpha6p antibody CD49 antigen-like family member F antibody CD49f antibody Integrin alpha6B antibody Integrin, alpha 6 antibody ITA6_HUMAN antibody ITGA6 antibody ITGA6B antibody Processed integrin alpha-6 antibody VLA 6 antibody VLA-6 antibody |
| Product description | Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. |
| Immunogen | recombinant protein |
Key Feature
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:1,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
Target Information
| Alternative Names | Alpha6p antibody CD49 antigen-like family member F antibody CD49f antibody Integrin alpha6B antibody Integrin alpha 6 antibody ITA6_HUMAN antibody ITGA6 antibody ITGA6B antibody Processed integrin alpha-6 antibody VLA 6 antibody VLA-6 antibody |
|---|---|
| Molecular Weight(MW) | 127 kDa |
| Cellular Localization | Cell membrane |
Database Links
| SwissProt ID | P23229Q61739Q63258 |
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Application
Application
Fig1: Western blot analysis of Integrin alpha 6 on Raji cell lysates using anti-Integrin alpha 6 antibody at 1/500 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Integrin alpha 6 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Integrin alpha 6 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti-Integrin alpha 6 antibody. Counter stained with hematoxylin.
| Positive Control | Raji, human colon cancer tissue, mouse colon tissue, mouse stomach tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:50-1:200 |
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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