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Product Profile
| Product Name | Desmin |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CMD1I antibody CSM1 antibody CSM2 antibody DES antibody DESM_HUMAN antibody Desmin antibody FLJ12025 antibody FLJ39719 antibody FLJ41013 antibody FLJ41793 antibody Intermediate filament protein antibody OTTHUMP00000064865 antibody |
| Product description | Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites. Although it is present early in the development of muscle cells, it is only expressed at low levels, and increases as the cell nears terminal differentiation. Desmin is also important in muscle cell architecture and structure since it connects many components of the cytoplasm. Finally, desmin may be important in mitochondria function. Desmin-related myopathy (DRM or Desminopathy) is a subgroup of the myofibrillar myopathy diseases and is the result of a mutation in the gene that codes for desmin which prevents it from forming protein filaments, instead forming aggregates of desmin and other proteins throughout the cell. Recently, mutations were identified in patients suffered by an arrhythmogenic right ventricular cardiomyopathy (ARVC). |
| Immunogen | peptide |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICCIHC |
| WB:1:1,000-1:2,000 ICC:1:200 IHC:1:200 | |
| Species Reactivity | HumanMouseZebra Fish |
| Concentration | 1mg/ml |
Target Information
| Alternative Names | CMD1I antibody CSM1 antibody CSM2 antibody DES antibody DESM_HUMAN antibody Desmin antibody FLJ12025 antibody FLJ39719 antibody FLJ41013 antibody FLJ41793 antibody Intermediate filament protein antibody OTTHUMP00000064865 antibody |
|---|---|
| Molecular Weight(MW) | 53 kDa |
| Cellular Localization | Cytoplasm |
Database Links
| SwissProt ID | P17661 |
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Application
Application
Fig1: Western blot analysis of Desmin on different cell lysates using anti-Desmin antibody at 1/2000 dilution. Positive control: Lane 1: Human skeletal muscle tissue Lane 2: Mouse heart tissue Lane 3: Human heart tissue
Application
Fig2: ICC staining of Desmin in HepG2 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining of Desmin in NIH-3T3 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4: ICC staining of Desmin in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-Desmin antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue using anti-Desmin antibody. Counter stained with hematoxylin.
Application
Fig7: Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-Desmin antibody. Counter stained with hematoxylin.
Application
Fig8: Western blot analysis of Desmin on hybrid fish (crucian-carp) brain tissue lysate using anti-Desmin antibody at 1/500 dilution.
| Positive Control | Human heart tissue, human skeletal muscle tissue, mouse heart tissue, human uterus tissue, mouse skeletal muscle tissue, HepG2,NIH-3T3,Hela |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 ICC:1:200 IHC:1:200 |
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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