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Product Profile
| Product Name | Integrin beta 1 [SA40-08] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | beta1 integrin antibody CD29 antibody Fibronectin receptor subunit beta antibody FNRB antibody Glycoprotein IIa antibody GP IIa antibody GPIIA antibody Integrin beta-1 antibody integrin VLA-4 beta subunit antibody Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) antibody ITB1_HUMAN antibody ITGB1 antibody MDF2 antibody MSK12 antibody OTTHUMP00000019420 antibody Very late activation protein, beta polypeptide antibody VLA BETA antibody VLA-4 subunit beta antibody VLA-BETA antibody VLAB antibody VLAbeta antibody |
| Product description | Integrins are transmembrane receptors that mediate the attachment between a cell and its surroundings, such as other cells or the extracellular matrix (ECM). Integrins are obligate heterodimers containing two distinct chains, called the α (alpha) and β (beta) subunits. The molecular mass of the integrin subunits can vary from 90 kDa to 160 kDa. Beta subunits have four cysteine-rich repeated sequences. Both α and β subunits bind several divalent cations. Integrins have two main functions: Attachment of the cell to the ECM and signal transduction from the ECM to the cell. However, they are also involved in a wide range of other biological activities, including immune patrolling, cell migration, and binding to cells by certain viruses, such as adenovirus, echovirus, hantavirus, and foot and mouth disease viruses. Research studies have implicated β1 integrin in various activities including embryonic development, blood vessel, skin, bone, and muscle formation, as well as tumor metastasis and angiogenesis. |
| Immunogen | recombinant protein |
Key Feature
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000-1:5,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRatZebra Fish |
| Concentration | 1mg/ml |
Target Information
| Alternative Names | beta1 integrin antibody CD29 antibody Fibronectin receptor subunit beta antibody FNRB antibody Glycoprotein IIa antibody GP IIa antibody GPIIA antibody Integrin beta-1 antibody integrin VLA-4 beta subunit antibody Integrin beta 1 (fibronectin receptor beta polypeptide antigen CD29 includes MDF2 MSK12) antibody ITB1_HUMAN antibody ITGB1 antibody MDF2 antibody MSK12 antibody OTTHUMP00000019420 antibody Very late activation protein beta polypeptide antibody VLA BETA antibody VLA-4 subunit beta antibody VLA-BETA antibody VLAB antibody VLAbeta antibody |
|---|---|
| Molecular Weight(MW) | 140 kDa |
| Cellular Localization | Cell Membrane, Cell projection, Cleavage furrow |
Database Links
| SwissProt ID | P05556P09055P49134 |
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Application
Application
Fig1: Western blot analysis of Integrin beta 1 on different cell lysates using anti-Integrin beta 1 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: NIH/3T3
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Integrin beta 1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Integrin beta 1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti-Integrin beta 1 antibody. Counter stained with hematoxylin.
| Positive Control | Hela, NIH/3T3, human liver cancer tissue, human colon cancer tissue, mouse stomach tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:5,000 IHC:1:50-1:200 |
Additional Information
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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